The Original Since 1947

Pure & Authentic Original
French Maritime Pine Bark Extract
and Vitis Vinifera Grape Seed

sixty years of science

Pure, Unadulterated and Authentic

For 60 years this scientifically-defined complex of small-cluster (oligomeric) proanthocyanidin molecules, now known as Flavay®, has produced stunning health results across Europe. Flavay® is totally safe to use—100% non-toxic and natural. It is well documented that this powerful antioxidant nutrient can benefit many different systems and body parts.

Improve Attention, Concentration, Learning, Mental Focus and Memory

Improve Attention, Concentration, Learning, Mental Focus and Memory

Originally proven and used for circulatory problems, inflammation and allergies, a more recent use of Flavay® has arisen among people suffering from a lack of concentration and attention. It is said to have begun quite accidentally when people took the product for another purpose, such as allergies, and noticed an improvement in concentration and mental focus—the classic symptoms of attention deficit.

Flavay® readily crosses the blood-brain barrier and enters into the regions of the brain where it provides superior antioxidant protection and improves circulatory efficiency through enhanced vascular strength and elasticity. This is significant as recent studies have established a connection between free radical damage and cognitive impairment. (MORE...)

Softer and Smoother Skin

Look & Feel Younger

Flavay® neutralizes the free radical reactions that are responsible for the progressive deterioration of your biological systems, including your brain. It's 100% bioavailable and its high free radical scavenging effect is believed to be associated with a longer, healthier, life with an increased functional life span. Flavay® protects against the breakdown of skin collagen, a process that produces visible signs of aging. (MORE...)

Softer & Smoother Skin

Visible signs of weak collagen are wrinkles and sagging skin. Flavay® works to strengthen and rebuild collagen. Through preserving your body's natural collagen proteins, Flavay® enhances the elasticity of your skin, helping to offset visible signs of premature aging. (MORE...)

Reduce Inflammation and Edema

Reduce Inflammation & Edema

Flavay® helps to improve capillary strength and reduces capillary leakage. It also helps support the body in maintaining healthy circulatory function your leg veins. (MORE...)

Healthier Cardiovascular System

Healthier Cardiovascular and Capillary Health and Better Circulation

Flavay® provides the nutritional support necessary for the maintenance of a healthy heart. Through reducing platelet aggregation, strengthening vascular membranes, and safeguarding against cellular destruction, normal blood flow is supported and maintained. (MORE...)

Improved Circulation

Healthy blood flow is essential to your health and life. Flavay® promotes a healthy circulatory system by strengthening capillary walls and micro-capillaries and improving capillary resistance and reducing leakage. (MORE...)

Healthier Eyes and Better Vision

Healthier Eyes & Better Vision

Through supporting the body's overall circulatory function, Flavay® enhances visual adaptation of the eye to different light environments. It also provides nutritional support in protecting the health of your retinas. (MORE...)

Strengthen a Weakened Immune System

Strengthen a Weakened Immune System

Flavay® helps in various ways to normalize your immune functions at the cellular level. First, Flavay® has the power to restore cytokine imbalances and can normalize white blood cell activity, thereby boosting immune function. Also, Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses, and host parasites. Finally, by recycling the activity of vitamins C and E—key players in the body's immune system—Flavay® helps your body to maintain its natural antioxidant defenses, giving your body more ammunition to fight infection. (MORE...)

Joint Relief

Joint Relief

Flavay® can selectively bind to the connective tissue of joints, preventing inflammation and lessening pain. And, the nutrients in Flavay® can be considered as 'collagen vitamins' because they partake in the biosynthesis of collagen and prevent its destruction. (MORE...)

Hay Fever and Allergy Relief

Hay Fever & Allergy Relief

Flavay® has been successfully used for controlling hay fever and allergies for many decades. Research now shows several ways that Flavay® may influence the immune response to help normalize the balance of chemicals in your body which control inflammation and allergies. (MORE...)

Sports Activities and Accelerated Recovery

Sports Activities and
Accelerated Recovery

Flavay® strengthens your body's collagen which is a major component of muscles, tendons, cartilage, ligaments and bones. Since Flavay® strengthens collagen, it can be helpful in minimizing damage potential and reducing the recovery time from sports-related activities. It can enhance the body's recovery following strenuous workouts. (MORE...)

Antioxidant Activity

Superior Antioxidant Activity

Unlike other antioxidants and bioflavonoids, Flavay® can penetrate both aqueous and lipid cellular membranes. It posses greater free radical scavenging capacity than other known antioxidants such as Vitamin C and E. Flavay® works to protect, support and restore the potency of Vitamins E & C as they work in the body. Flavay® is the product—used in the actual experiments—by which Dr. Jack Masquelier established the "radical scavenger effect." (MORE...)

REFERENCES:

Masquelier, J. A lifetime devoted to OPC and pycnogenol. Alfa Omega Editrice, Pub., 1996.
Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice, Publishers, 1995.
Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding of pycnogenol to elastin affects its rate of degradation by elastases. Biochem Pharmacol, 33: 3933-3939, 1984.
Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers extracted from ‘vitus vinifera l.’ in the rat. European Journal of Drug Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30.
Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging activity of proanthocyanidolic oligomers encapsulated in glycospheres: an in vivo and in vitro study. Cosmetology Department & S Biovectors, Ramonville St. Agne France. pp. 1-9.
Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Medica, May 26, 1986. pp. 12-15.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques chez l’animal-activite aniagoniste vis-a-vis des mediateurs de l’inflamation. Sanofi Res Toul Cedex Fr, pp. 31-40.
Beylot, C., Bioulac, P. Essai therapeutique d’un angioprotecteur peripherique, l’Endotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24, 1980.
Sarrat, L. Abord therapeutique des troubles fonctionnels des membres inferieurs par un microangioprotecteur l’Endotelon. Bordeaux Med, 11:685-8, 1981.
Delacroix, P. Etude en double aveugle de l’Endotelon dans l’insuffisance veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981. pp. 1793-1802.
Masquelier, J. pycnogenol: recent advances in the therapeutical activity of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant Research and Journal of Natural Products, July 1980 pp. 243-256.
Henning, B., et al. Lipid peroxidation and endothelial cell injury: implications in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106.
Masquelier, J. “Les procyanidols du vin leur role dans l’alcoolisme.” pp. 88-93.
Gazave, J.M. “Notions recentes sur les capillaires” unpub. bulletin from the Laboratoire De Physiologie Patholigie pp. 26-29.
Ruf, J.C. Wine and polyphenols related to platelet aggregation and atherothrombosis. Office International Vigne et du Vin, Nutrition and Health Unit, Paris France; Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131), 1999.
Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin. Acta Physiologica Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980.
Shaw, R. How [Australian] PycnoGenol [MASQUELIER’s®] Helps Sports People.
Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet Arom 95:89-97, 1990.
Masquelier, J., et al. “Flavonoids et pycnogenol” Int J Vit Nut Res, (49)3:307-311, 1979.
Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol. 25(2):135-9, 1987.
Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica Report, 1971.
Laparra, J., et al., Acta Therapeutica, 4:233, 1978.
Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co., projects 143010 & 143021; Feb. 1989.
Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover, Germany, 1967-1971.
Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux, 129:51-65, 1990.

*Statements made herein have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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