Flavay’s® strong antioxidant power acts as a “scavenger”
of the free radicals that play a major role in the initiation, duration
and breakdown of inflammation. That means that your immune system works
better, your joints hurt less, and your blood flows better—all because
of Flavay®.
Flavay® prevents free
radical damage to macrophages, a type of white blood
cell that generates nitric oxide to destroy bacteria,
viruses and parasites.
A strong immune system is the cornerstone of good health as it protects
your body against disease. There are several important ways that Flavay®
can nourish and invigorate your immune system. First, Flavay® helps
to normalize immune functions at the cellular level. Flavay® prevents
free radical damage to macrophages, a type of white blood cell that generates
nitric oxide to destroy bacteria, viruses and parasites. However, if nitric
oxide is overproduced it turns on its host and damages the macrophages—thereby
impairing immune function. Thus, phrases such as "double-edged sword"
are frequently applied to nitric oxide in health and disease. This emphasizes
the importance of another way that Flavay® benefits the immune system:
regulating nitric oxide in the body. Research shows that Flavay®
can help to maintain the optimal level of this free radical by helping
the body to produce adequate levelsand to neutralize nitric oxide
where it does harm.
Finally, by increasing the activity of vitamins C and E in the body,
Flavay® helps the body maintain its antioxidant defenses, giving
your immune system more ammunition to fight infection.
How Your Immune System Works
Although it's called a "system," the immune system is not associated
with one particular organ but it's a collection of cells that "speak"
to one another—and with the rest of the body— through chemical
messengers (the immunotransmitters) and thereby work in close harmony
to protect the body from the harmful effects of bacteria, viruses, parasites
and environmental toxins.
Macrophages are your immune system's foot soldiers, capable of engaging in hand-to-hand combat
as they literally gobble up invaders to destroy them.
The most important components of the immune cells are the white blood
cells (lymphocytes), which include T-cells, B-cells and macrophages. Macrophages
are the immune system's foot soldiers, capable of engaging in hand-to-hand
combat as they literally gobble up invaders to destroy them.
The white blood cells depend upon immunotransmitters called "cytokines"
to communicate with one another and to coordinate their ferocious activity.
Cytokines are to the immune system what neurotransmitters are to the brain.
Just as the brain relies upon neurotransmitters to exchange information
among its neurons and with the rest of the body, so your immune system
depends upon cytokines.
When your body is threatened by an invasion, cytokines signal your immune
system to mobilize reserve troops of white blood cells. When the invasion
is over, your cytokines are responsible for sending the signals to stop
mobilizing the troops. In other words, these immunotransmitters coordinate
your white blood cells, boosting their activity at times of infection,
injury, or other demands and reining them back in after battle.
Flavay® Normalizes Immune Cell
Functions and
Actually Boosts Immune Function
Flavay® can restore
cytokine imbalances and thereby normalize
white blood cell activity—normalizing your immune function.
When the body fights off an infection, the cytokines go to work, sending
messages to the brain that cause more white blood cells to mobilize. The
more white blood cells your body activates, the more free radicals they
produce. These free radicals are among your immune system's most powerful
weapons, as a response to injury and during times of disease, emotional
stress and aging. Research demonstrates that Flavay® has the power
to restore cytokine imbalances and can normalize white blood cell activity,
thereby normalizing immune function.
Flavay® Scavenges
Rampaging Free Radicals
Free radicals are like pellets of poison that destroy invaders by interfering
with their cellular machinery, literally dissolving or breaking down the
genetic material of bacteria, toxins and viruses.
When all is going well, the immune system is capable of identifying foreign
invaders such as viruses and bacteria by accurately "reading"
molecular codes found on cell surfaces. These molecular codes are like
flags of different armies, and the immune system will not attack a cells
if it "reads" a flag belonging to the body's own host army.
Unfortunately, however, free radicals can interfere with the biological
components of our healthy cells, just as they destroy invaders. This leads
to many diseases.
Nitric Oxide Toxicity and Abnormal Immune
Responses
Contemporary research shows
that elevated levels of nitric oxide appear to contribute
to arthritis and other disorders associated to abnormal immune
responses.
Contemporary research shows that elevated levels of nitric oxide (sometimes
referred to as "NO") appear to contribute to a number of seemingly
different disorders that all have a common element of abnormal immune
or inflammatory responses.
Studies of arthritis, colitis, and other inflammatory disorders have
all demonstrated elevated levels of nitric oxide synthesis. In the case
of arthritis, nitric oxide has been implicated in the destruction of the
pericellular and extracellular matrix of cartilage in arthritis.
Arthritis is an umbrella term for more than 100 different conditions
that produce either inflammation of connective tissue (joints and tendons)
or degeneration of the articular cartilage, a wearing down of the protective
covering that cushions the ends of bones, allowing bones to rub together
without causing damage to the joints.
When joints become arthritic, they become inflamed and enlarged, interfering
with the normal flow of blood. For example, when you bend an arthritic
knee, you cut off blood flow to the area which sets into motion of a chain
of events that will lead to a burst of free radicals when the blood flow
returns (known as "reperfusion injury"). When you release the
knee, a proliferation of free radicals causes the area to become even
more inflamed, contributing to the degeneration of the joint, which becomes
more swollen and worn down.
High levels of nitric oxide have also been implicated in the inflammation
that is associated with asthma. Asthmatics exhale significantly higher
levels of nitric oxide and type II nitric oxide synthase (also known as
"NOS") expression is increased in biopsy specimens from asthmatics.
It's long been recognized that nitric oxide is essential for normal blood
circulation as it controls the muscular tone of blood vessels and regulates
circulation and blood flow. However, excessive amounts of nitric oxide
can be deadly to the cardiovascular system and actually contribute
to disease and inflammation. High levels of nitric oxide can restrict
blood flow and promote production of more free radicals, including the
dangerous peroxynitrate.
Flavay® can help regulate
a healthy balance of nitric oxide in your body.
Flavay® can significantly scavenge nitric oxide radicals. However,
as we'll discuss next, your body needs a certain amount of nitric oxide
in order to maintain good health. Nitric oxide is paradoxical. It can
both mediate normal physiological functions and it can be highly toxic.
Nitric oxide can act as an anti-inflammatory under normal health conditions,
but it can have the opposite effect and cause more inflammation to an
already inflamed area when overproduced. The key, therefore, is to maintain
the optimum balance of this double-edged sword, nitric oxide.
When the immune system's cytokines activate macrophages (the white blood
cells capable of gobbling up invading viruses and bacteria), the macrophages
produce large amounts of nitric oxide in the course of battle. Nitric
oxide is a colorless gas produced by many different cells in the body
that, depending on the situation, can be very good or very
bad. Nitric oxide plays several important roles in the body:
- Nitric oxide is an important signaling molecule that turns genes
on and off.
- By controlling the muscular tone of blood vessels, nitric oxide
regulates the circulation and normalizes blood flow.
- Nitric oxide modulates communication between brain cells and is
instrumental in helping us concentrate and learn new information,
and also in maintaining memory.
- When produced by immune cells, nitric oxide fights infection, kills
tumor cells and promotes wound healing.
- Nitric oxide is essential for perceiving pleasure and pain, and
it helps translate sexual excitement into penile erections.
- Nitric oxide aids in digestion of food by helping to control gastric
movements.
But nitric oxide can be very destructive under other circumstances:
- Nitric oxide restricts blood flow.
- When produced in excess by immune cells, nitric oxide can trigger
chronic inflammation, which can cause arthritis, colitis, inflammatory
bowel disease and possibly cancer.
- Nitric oxide promotes production of more free radicals.
- In the brain, nitric oxide can hamper mental function and cause
memory loss and brain aging.
The real trouble starts when nitric oxide encounters the superoxide free
radical and becomes peroxynitrate, which destroys antioxidants like glutathione,
vitamin E and common flavonoids, and damages proteins in the body. The
good news is that Flavay® scavenges peroxynitrate and has a remarkable
modulatory effect on nitric oxide—helping to maintain optimal levels
in the body and neutralizing this free radical where it does harm.
“Radical Scavenger” Effect of Flavay®
Flavay® is the product—used in the actual experiments—by
which Dr. Jack Masquelier established the "Radical
Scavenger Effect."
Flavay’s® strong antioxidant power acts as a scavenger
of the free radicals that play a major role in the initiation, duration
and breakdown of inflammation. That means that your immune system works
better, your joints hurt less, and your blood flows better, all because
of Flavay®.
"[A] method for preventing and fighting the harmful biological
effects of free radicals in the organism of warm blooded
animals and more especially human beings, namely cerebral involution,
hypoxia following atherosclerosis, cardiac or cerebral infarction,
tumour promotion, inflammation, ischaemia, alterations
of the synovial liquid, collagen degradation, among
others. The method consists in administering to said animals and
especially to human beings an amount, efficient against said effects,
of a plant extract with a proanthocyanidins content which has a
radical scavenger effect"Dr. Jack Masquelier,
1987.
Our Customers Say: “I've been suffering with carpal tunnel syndrome in both of my wrists for over three years. I also have two active preschoolers, whom I adore, so having carpal tunnel has been really, really painful. My doctor recommended surgery for my wrists but I decided to listen to my brother who suggested that I first try Flavay® and Flavay Plus®. After taking three of each every day for over two months, I no longer have any pain! I can hardly believe it! My kids are happier and so am I because I'm able to take care of them without pain! Thank you so much!”
—Ms. A. S.
Superior Antioxidant Support
Flavay® is superior to other antioxidants because its protective
effects are multiplied in the body. While it provides its own, powerful
antioxidant protection, it also supports the dynamic interplay between
other antioxidants in the body. Flavay’s® ability to recycle,
or regenerate vitamins C and E after they have quenched free radicals
vastly extends their unique antioxidant powers, helping to maintain an
optimal, synergistic antioxidant balance in the body.
Flavay® is rapidly absorbed and very quickly distributed throughout
the body. As a free radical fighter, Flavay® comes to the aid of
the body more quickly than other antioxidants, reducing the potential
for free radical damage and the ravages of aging. Flavay® also possesses
more reactive sites for neutralizing free radicals than other known antioxidants.
Furthermore, Flavay® permits reactivity with both positively and
negatively charged free radical species. What this means is that Flavay®
can quench or scavenge (neutralize) a broad variety
of free radicals. Highly reactive as an antioxidant in both lipid (fat)
and aqueous (water) phases, Flavay® neutralizes oxygen free radicals
and is a valuable protector of healthy cells in a variety of internal
conditions. This is a unique property among antioxidants, as most work
either in lipid or aqueous phases, but not both. As a free radical scavenger,
Flavay®
is like an antioxidant prize fighter that can successfully take on all
challengers, big or small, in any kind of weather
All of this means that your immune system works better so
that your joints hurt less and your blood flows better—with Flavay®.
REFERENCES:
Masquelier, J. A lifetime devoted to OPC and pycnogenol. Alfa Omega Editrice,
Pub., 1996.
Schwitters, B., Masquelier, J. OPC in practice. Alfa Omega Editrice, Publishers,
1995.
Kilham, C., Masquelier, J. OPC: The miracle antioxidant. Keats Publishing,
Inc., 1997.
Packer, L., et al. The antioxidant miracle: your complete plan. John Wiley
& Sons, Inc., 1999.
Packer, L., et al. Antioxidant food supplements in human health. Academic
Press, 1999.
Lincoln, J., Hoyle, C.H.V., Burnstock, G., Nitric oxide in health and disease.
Cambridge University Press, 1997.
Moncada, S., Nistico, G., Bagetta, G., Higgs, E.A. Nitric oxide and the
cell. Princeton University Press, 1998.
Facino, R.M., et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
Passwater, R.A. The antioxidants: the nutrients that guard your body. Keats
Publishing, Inc., 1985.
Barilla, J. et al. The nutrition superbook: volume 1: the antioxidants.
Keats Publishing, Inc., 1995.
Facino RM, et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from Vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
Kuttan R, et al. Collagen treated with catechin becomes resistant to the
action of mammalian collagenase. Experientia, 37: 221-223, 1981.
Masquelier, J., et al. Stabilization du collagene par les oligomeres procyanidoliques.
Acta Therapeutica, 7:101-105, 1981.
Masquelier, J. Aspects pharmacologiques nouveaux de certains flavonoides.
A Vie Medical 12:1969.
Laparra, J., et al. Etude pharmaco-cinetique des oligomers procyandoliques
totaux du raisin. Acta Therapeutica, 4, 1978.
Laparra, J., et al. Etude pharmacocinetique des oligomeres flavonoliques.
Plantes med et phyto, Tome XI, pp. 133-142, 1977.
Robert A.M.; Groult, N.; Six, C.; Robert, L. Etude de laction des
oligomeres procyanidoliques sur des cellules mesenchymateuses en culture.
Ii lattachment des fibres elastiques aux cellules. (Study of the effect
of procyanidolic oligomers on mesenchymal cells in culture. Ii attachment
of elastic fibers to the cells.) Pat Biol, (30)6:601-7, 1990.
Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular and crystal
structure of (+)-2,3-trans-3,4-trans-leucocyanidin [(2r,3s,+r)-(+)-3,3,
4.4, 5.7-Hexahydroxyflavan] dihydrate, and comparison of its
heterocyclic ring conformation in solution and the solid state. Journal
of the Chemical Society; Perkin Transactions I 1985. pp. 1413-17.
Masquelier, J. Proanthocyanidins et radicaux libres. 1985.
Uchida, S., et al. Condensed tannins scavenge active oxygen free radicals.
Med Sci Res, (15) 1987. pp. 831-832.
Ariga, T. Radical scavenging action and its mode in procyanidins b-1 and
b-3 from azuki beans to peroxyl radicals. Agric Biol Chem, 54(10) 1990.
pp. 2499-2504.
Da Silva, R., et. al. Radical scavenger capacity of different procyanidins
from grape seeds. Presented at a symposium, Free radicals in biotechnology
and medicine. Royal Society Of Chemistry, London January 1990, pp.
79-80.
Bauman, J., Wurm, G., Bruchhausen, F. Hemmung der prostagladinsynthetase
durch flavonoide und phenolderivate im vergleich nit deren 02 radikalfangereigenschaften
Arch Pharm, (Weinheim) 313 (1980) pp. 330-337.
Lombard, J., et al. The brain wellness plan. Kensington Pub. Corp., 1998.
Flesch M., et al., Effects of red and white wine on endothelium-dependent
vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 1998;275:1183-94.
Fitzpatrick, D.F., Fleming R.C., Bing B, Maggi DA, O'Malley RM. Isolation
and characterization of endothelium-dependent vasorelaxing compounds from
grape seeds. J Agr & Food Chem In press.
Fitzpatrick, D.F., Maggi D, Bing B, Coffey RG. Vasorelaxation, endothelium,
and wine. BioFactors 1997;6:455-459.
Fitzpatrick, D.F., Hirschfield SL, Ricci T, Jantzen P, Coffey RG. Endothelium-dependent
vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol
1995;26:90-95.
Fitzpatrick, D.F., Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing
activity of wine and other grape products. Amer J Physiol 1993;265:H774-H778.
Kuttan, R., Donnelly, P.V., Di Ferrante, N. Collagen treated with catechin
becomes resistant to the action of mammalian collagenase. Experientia, 37:
221-223, 1981.
Masquelier, J. Procyanidolic oligomers. J Parums Cosm Arom, 95: 89-97, 1990.
Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding
of pycnogenol to elastin affects its rate of degradation by elastases.
Biochem Pharmacol, 33: 3933-3939, 1984.
Kakegawa, H., et al. Chem. Pharm. Bull. 33:5079, 1985.
Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers extracted
from vitus vinifera l. in the rat. European Journal of Drug
Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30.
Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging activity
of proanthocyanidolic oligomers encapsulated in glycospheres: an in vivo
and in vitro study. Cosmetology Department & S Biovectors, Ramonville
St. Agne France. pp. 1-9.
Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting
enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Medica,
May 26, 1986. pp. 12-15.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez lanimal-oedenme de la patte. Sanofi Res Toul Cedex Fr, pp31-40.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez lanimal-activite aniagoniste vis-a-vis des mediateurs de linflamation.
Sanofi Res Toul Cedex Fr, pp. 31-40.
Dubos, C., Durst, G., Hugonot, H. Evolution de la resistance capillaire,
spontanement ou artificiellement diminuee par laction dune substance
capillaro-toxique chez des personnes agees--action benefique dun agnet
actif sur la micro-circulation: lEndotelon. Inform. Therapeut. 1980.
pp. 302-305.
Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude dun
microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990.
Lagrue, G., Olivier-Martin, F., Grillot, A. Etude des effets des oligomeres
du procyanidol sur las resistance capillaire dand lhypertension arterielle
et certaines nephropathies. Sen. Hosp. Paris 18-25 Septembre, 1981.
Beylot, C., Bioulac, P. Essai therapeutique dun angioprotecteur peripherique,
lEndotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24,
1980.
Lesbre, F.X., Tigaud, J.D. Effect de lEndotelon sur lindice
de fragilite capillaire dan une population specifique: les sujets cirrhotiques.
Gaz. Med. de France, (90)24 1983.
Sarrat, L. Abord therapeutique des troubles fonctionnels des membres inferieurs
par un microangioprotecteur lEndotelon. Bordeaux Med, 11:685-8, 1981.
Delacroix, P. Etude en double aveugle de lEndotelon dans linsuffisance
veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981.
pp. 1793-1802.
Thebaut, J.F, Thebaut, P., Vin, F. Etude de lEndotelon dand les manifestations
fonctionnelles de linsuffisance veineuse peripherique-resultats dune
etude en double aveugle portant sur 92 patients. Gazette Medicale,
(92)1, 1985. pp. 96-100.
Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and arachidonate
metabolism in platelets by procyanidins. Prostagland Leukotri Essent Fatty
Acids, 38:181-8, 1989.
Masquelier, J. pycnogenol: recent advances in the therapeutical activity
of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant
Research and Journal of Natural Products, July 1980 pp. 243-256.
Henning, B., et al. Lipid peroxidation and endothelial cell injury: implications
in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106.
Masquelier, J. Les procyanidols du vin leur role dans lalcoolisme.
pp. 88-93.
Gazave, J.M. Notions recentes sur les capillaires unpub. bulletin
from the Laboratoire De Physiologie Patholigie pp. 26-29.
Ruf, J.C. Wine and polyphenols related to platelet aggregation and atherothrombosis.
Office International Vigne et du Vin, Nutrition and Health Unit, Paris France;
Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131),
1999.
Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin. Acta Physiologica
Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980.
Tayau, M.F, LeFevre, G. Action du leucocyanidol sur lhyalaluronidase.
Bull Soc Pharm Bordeaux, 95:132-136, 1956.
Lamy, M. Utilization des oligomeres procyanidoliques en gynecologie. Essai
Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22.
Henriet, J.P Une Etude Exemplaire Pour Un Phlebotrope: letude
EIVE. Unpub., pp. 77-83.
Pfister, A., Simon, M.T., Gazave, J.M. Sites de fixation des oligomeres
procyanidoliques dans la paroi des capillaires sanguins du poumon decobaye.
Acta Therapeutica (8) 1982. pp. 223-237.
Kuttan, R., Donnelly, P., Di Ferrante, N. Collagen treated with (+)
-catechin becomes resistant to the action of mammalian collagenase.
Laboratory of Connective Tissue Research, Dept. of Biochem. Baylor Col.
of Med., Houston TX. 28, May, 1980.
Gendre, P., Laparra, J., Barraud, E. Effect protecteur des oligomeres
procyanidoliques sur le lathyrisme experimental chez le rat. Ann.
Pharm. Francaises, (43)1, 1985 pp. 61-73.
Corbe, C., Boissin, J.P., Siou, A. Light vision and chorioretinal circulation.
Study of the effect of procyanidolic oligomer (Endotelon). Jn. Fr. Opthalmol,
(11)5:453-460, 1988.
Boissin, J.P., Corbe C., Siou, A. Chorioretinal circulation and dazzling:
use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol Fr, 88(2):173-4,
177-9, 1988.
Proto, F. et al. Electrophysical study of vitis vinifera procyanoside oligomers
effects on retinal function in myopic subjects. Ann Ott Clin Ocul, 114:85-93,
1988.
Saracco, J.B., Estachy, G.M. Etude d lEndotelon en opthalmologie.
Gaz Med de France, 88:2035-2038, 1981.
Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies.
Klin Monatsbl Augenheilkd, 178:386-389, 1981.
Corbe, C., et al. Microangiopathy of the retina. J. Fr. Opthalmol, 11:453,
1988.
Verin, M.M., Vildy, A., Maurin, J.F., Retinopathies et O.P.C. Bordeaux Medicale,
(16)11. pp. 1467-74, 1978.
Soyeux, A. et al. Endotelon. Diabetic retinopathy and hemorheology. Bull
Soc Ophtalmol Fr. 87(12):1441-4, 1987.
Fromantin, M. Les oligomeres procyanidoliques dans le traitement de
la fragilite capillaire et de la retinopathie chez les diabetiques. A propos
de 26 cas. Med Int, 16(11):432-434, Nov. 1981.
Arne, J.L. Contribution a letude des oligomeres procyanidoliques:
Endotelon, dans la retinopathie diabetique (a propos de 30 observations).
Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982.
Baruch, J. Effect of Endotelon in postoperative edema. Results of a double-blind
study versus placebo in 32 female patients. Ann Chir Plast Esthet 29(4):393-5,
1984.
Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism in
rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981.
Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica,
9:355-374, 1972.
Havsteen, B. Flavonoids, a class of natural products of high pharmacological
potency. Biochem Pharmacol, 32:1141-48, 1983.
Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J. Berkhauser
Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger., 1977.
Masquelier, J. Action protectrice du vin sur lulcere gastrique. Resultats,
p. 61.
Amella, M., et al. Inhibition of mast cell histamine release by flavonoids
and bioflavonoids. Planta Medica, 5116-20, 1985.
Shaw, R. How [Australian] PycnoGenol [MASQUELIERs®] Helps Sports
People.
Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet
Arom 95:89-97, 1990.
Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques
(Endotelon) dans le traitement des lymphoedemes post-therepeutiques de members
superieurs. Symposium Satellite, Congres International dAngiologie,
Toulouse, France, 4-7 Oct. 1989.
Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during 2 weeks
of intense training. Abstract submitted to national meeting of the Amer
College of Sports Medicine, June 1998.
Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting by
chronic phosphatidylserine administration of the stress-induced activation
of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm
43: 385388, 1992.
Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine
administration during two weeks of resistive exercise-induced overtraining.
Bio of Sport 15(3):135-44, 1998.
Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres procyanidoliques
sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux,
1976.
Masquelier, J. Action comparee de divers facteurs vitaminiques p sur loxydation
de lacide ascorbique par les ions cuivriques. Bull. de la Societe
de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304.
Masquelier, J. Action comparee de divers facteurs vitaminiques p sur lacide
ascorbique-oxydase. Bull. de la Societe de Chimie Biologique XXXIII (3,4)
1951. pp.304-306
Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G., Mishioka,
I. Inhibitory effects of tannins on hyaluronidase activation and on
the degranulation from rat mesentery mast cells. Chem. Pharm. Bull.
33(11)1985. 5079-5082.
Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J. Histamine
and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress
ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase
in vitro. Dirkhauser Verlag,Vol. 7/1, 1977.
Pariente, J.J. Parientl-Amsellem, J. Les oedemes post-traumatoqies
chez le sportif: essai controle de lEndothelon. Actualite Therapeutique
90(3) 2/11 1983 pp. 231-235.
Masquelier, J., et al. Flavonoids et pycnogenol Int J Vit Nut
Res, (49)3:307-311, 1979.
Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol.
25(2):135-9, 1987.
Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica
Report, 1971.
Laparra, J., et al., Acta Therapeutica, 4:233, 1978.
Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells
of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co., projects
143010 & 143021; Feb. 1989.
Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover,
Germany, 1967-1971.
Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable
extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux,
129:51-65, 1990.