Placebo controlled studies and double-blind trials proved that young, university students experienced significantly less stress from tests, stayed more clear-headed and composed, and kept a more stable mood. (148, 149)
Researchers found that Flavay® worked as well as commonly prescribed medications, including Ritalin, on children and adults diagnosed with attention disorders. (6) The difference is that Flavay® nourishes the brain.*
A Completely Safe, Non-Drug Natural Approach
to Normalizing Healthy Brain Function
Flavay® is totally safe, a 100% non-toxic and natural, but powerfully effective, nutritional supplement. Flavay® is a highly specialized, nutritional complex of pairs and triples of a specific molecule called "flavan-3-ol," isolated from natural extracts, that has been extensively tested and examined clinically for biological antioxidant protection, collagen strengthening, tissue rebuilding, and other health producing outcomes.
Manufactured and used in France since 1950 for circulatory problems, inflammation and allergies, a more recent use of Flavay® has arisen among people suffering from a lack of concentration and attention. It is said to have begun quite accidentally when people took the product for another purpose, such as allergies, and noticed an improvement in concentration and mental focus—the classic symptoms of attention deficit.
Scientifically, how could this possibly be true? How could molecules extracted from mundane vegetal sources have a profound influence on the brain? According to scientific research, there are a number of mechanisms of action.
Many decades of studies have established that Flavay® improves circulation, including microcirculation in the brain. Flavay® is one of the few dietary antioxidants that readily crosses the blood-brain barrier to protect brain cells. The blood-brain barrier protects the brain from compounds that normally circulate in the blood. Brain cells are very sensitive to some compounds, even though they may not damage other cells in the body or even be needed by other cells. In laboratory experiments in which blood is rapidly injected into brain blood vessels, dramatically increasing the blood pressure within those vessels for a brief time, Flavay® shows a significant protective effect. (1, 2, 3)
Flavay’s® antioxidant protection of brain cells is significant as recent studies have established a connection between free radical damage and cognitive impairment. Research demonstrates that Flavay® helps regulate nitric oxide: a colorless gas produced by many different cells in the body: from endothelial cells on the walls of the arteries to the neurons in the brain to the disease-fighting cells of the immune system. Nitric oxide modulates communication between brain cells and is thereby deeply involved in concentration, learning and memory. And, by controlling the muscular tone of blood vessels, nitric oxide regulates circulation and normalizes blood flow. As long as nitric oxide is produced in the right amount, it is beneficial to the body. Overproduction of nitric oxide, however, promotes production of more free radicals in the brain, which can hamper mental function and cause memory loss and brain aging. Thus, Flavay’s® ability to help maintain the optimal level of nitric oxide profoundly influences brain (and immune) functions. (4, 5)
There is also evidence that Flavay® may help the body to regulate enzymes which control the crucial neurotransmitters dopamine and norepinephrine, chemicals that carry messages among brain cells and are involved in excitatory responses. Flavay’s® ability to support healthy blood flow to the brain is also important to brain function. Researchers have shown that decreased blood flow to the brain plays a major role in age-related brain disorders. Flavay® may also help deliver other nutrients to the brain, such as zinc and selenium, which are essential to normal brain function, according to recent research. Preliminary studies have confirmed what many users of this remarkable complex have experienced: striking benefits in improved concentration and mental focus, the classic symptoms of attention deficit disorder. (6, 1, 2)
Dr. Jack Masquelier.
A preliminary study by a psychologist in Tulsa, Oklahoma, who specializes in treating attention deficit disorder, found striking benefits from these naturally-derived molecules, known as Flavay®. The researchers found that it worked just as well as the commonly prescribed stimulant medications, including Ritalin, on thirty children and adults diagnosed with ADD. The subjects were given a battery of computerized and behavior tests to judge their attention, concentration, and other important factors in ADD under various circumstances: when they were either on or off their usual stimulant medications, or on Flavay® alone. When they were off their medications, their ADD deteriorated. On their medications, they were much improved. But when they took daily doses of Flavay®, their scores and behavior were just as improved as when they took stimulant drugs. Many of the subjects also had other positive effects. (6)
This nontoxic, water soluble nutrient holds promise as an alternative to Ritalin. Many children with ADD have found this substance effective to decrease their symptoms by normalizing brain function. It seems to improve memory by improving circulation to the brain. Free radicals reprogram DNA and have been implicated in more than sixty diseases. Flavay® has been shown to help in inflammation of the joints and other tissues, as well as improve functioning of the circulatory, nervous and immune systems. (7, 3)
Flavay® Supports The Brain-Immune Connection
Top research institutions worldwide now understand that there is a two-way chemical dialog between the brain and the immune system. Each can influence the other directly. There is an ongoing chemical dialog between the brain and the immune system, a connection that depends on two languages: the neurotransmitters of the brain, and the immunotransmitters of the immune system. (4)
Flavay® supports your immune system in several important ways. First, by recycling the activity of vitamins C and Ekey players in the body's immune systemFlavay® gives the body more ammunition to fight infection. Second, research demonstrates that Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses, and host parasites. (2, 8, 4)
As long as nitric oxide is produced in the right amount, it is beneficial
to the body; nitric oxide fights infection, kills tumor cells, and promotes
wound healing. But when nitric oxide is produced in excess, it throws
the brain-immune connection off kilter and causes some of the brain's
worst free radical damage. Over the past decade, scientists have shown
that the production of nitric oxide through the combination of immune
and nervous system activity (often sparked by an infection, exposure to
a toxin, or as part of the aging process) plays a key role in the development
of neurological diseases. Thus, Flavay’s® ability to help
regulate nitric oxide can profoundly benefit the bodys immune and
brain functions. (4)
—Ms. Danielle S.
Flavay Plus® uses a synergistic blend of Flavay® with antioxidant vitamins, minerals and other phytonutrients to best take advantage of the dynamic interplay among the key antioxidants and their co-factor nutrients.
Phosphatidyl serine: Flavay Plus® is formulated with phosphatidyl serine (Leci-PS), a complex of amino and fatty acids extracted from soy lecithin, which has proven to be a safe, potentially effective therapeutic agent in treating memory deficit disorders and is an often-used supplement for attention deficit disorders. Phosphatidyl serine has been the subject of many human clinical trials regarding memory loss, mood, cognitive performance, learning ability and stress. Many studies show that phosphatidyl serine can optimize cognition. In the most famous human study, researchers gave 300 mg of phosphatidyl serine a day for 12 weeks to 149 subjects over 50. Various memory and learning tests were administered before and after. The results showed that phosphatidyl serine managed to raise cognitive performance to the levels typical for as much as 12 years younger. (9-11)
In a study where a group of 27 ADHD children took 200 to 300 mg of phosphatidyl serine daily for four months, researchers found that 25 children exhibited improvement in learning capacity and behavior; and the researchers noted that there were no adverse affects. This substance also has the potential to stimulate the brain to produce dopamine. Published, double-blind research shows that phosphatidyl serine can also be helpful for depression. (9-11)
—Mr. David S.
Phosphatidyl serine is a phospholipid that is vital to brain cell structure and function. Phospholipids are molecules containing both amino and fatty acid components, which are found in every cell membrane in our bodies. Phosphatidyl serine plays an important role in our neurotransmitter systems, in metabolism levels of the brain, and in maintaining nerve connections in the brain. It appears to help reestablish the normal down-regulation of cortisol secretion that is increased in chronically stressed individuals, and its benefit in dementia and depression may relate to improved brain cell membrane fluidity. In the clinical studies, phosphatidyl serine (100 mg three times daily) has been shown to improve the mood and mental function in those with Parkinsons disease. (9-14)
Scientific studies have demonstrated that phosphatidyl serine supplementation can increase the output of acetylcholine, the neurotransmitter so important to memory. Clinical trials with elderly patients suffering from memory deficit disorders have shown that adding phosphatidyl serine to the daily diet improved the ability of these patients to think and decreased behavioral disturbances. In other studies, phosphatidyl serine also improved the performance of patients with age-associated memory impairment, a disorder affecting millions of Americans each year. (13)
Flavay Plus® Helps With Stress and Cortisol
The Journal of Autism and Developmental Disorders reported that children with ADHD experienced abnormal rhythms in the stress hormone cortisol. (15, 4)
Research has shown that phosphatidyl serine works to keep the brains processes within normal limits, raising them when they are low and lowering them when they are high. So phosphatidyl serine boosts the weak stress response in the elderly person and calms down exaggerated stress in the healthy young person. Both physical and mental stressful conditions cause stress hormones to be released into circulation, even in the young and healthy. Phosphatidyl serine given to athletes prior to starting exercise produced an impressive degree of down-regulation of the stress hormones. Phosphatidyl serine may have the capacity to normalize the stress-induced activation of the hypothalamic-pituitary-adrenal axis. In a double-blind, placebo-controlled study conducted in Italy, phosphatidyl serine lowered stress hormone (cortisol) production by 30 percent. (16)
—Mr. and Mrs. P.
Two more recent placebo controlled studies confirmed the earlier double-blind trials; young, university students experienced significantly less stress from tests when they took phosphatidyl serine (300 mg daily for 30 days), they stayed more clear-headed and composed, and kept a more stable mood. (17, 18)
Altogether, this research shows that Flavay Plus® can help young people confront the stressful challenges of living in today's world.
Ginkgo biloba leaf: Flavay Plus® also includes standardized ginkgo biloba leaf extract, primarily known as a brain booster. In Germany and France, ginkgo biloba extract is commonly prescribed for mental problems that are often caused by poor circulation to the brain, such as difficulty concentrating, poor memory, confusion, depression, and anxiety. There have been numerous European studies conducted on ginkgo biloba extract and many have reported positive effects in terms of memory and acuity. Recently, the New York Institute for Medical Research conducted a double-blind, placebo-controlled study using ginkgo biloba extract on patients suffering from dementia (caused by either stroke or Alzheimers disease), with positive results. This is significant because there are few drugs that have any impact at all on cases of dementia. And, the study was published in a mainstream medical journal. (19)
Vitamin A (Beta-carotene and cartenoids): Flavay Plus® contains the preferred form of Vitamin A, beta-carotene (Betatene™). Beta-carotene is converted by the body into vitamin A only as the body needs it and what isn't converted remains as a powerful antioxidant, shown to be a cancer preventative, shown to strengthen the immune system and benefit the eyes and cardiovascular system. The beta-carotene in Flavay Plus® is the highest quality, full-spectrum, patented Betatene™, a complete array of plant-derived, antioxidant cartenoids: beta-carotene, alpha-carotene, cryptoxanthin, zeaxanthin, lutein, and lycopene. (20, 21)
B-Vitamins: Flavay Plus® is also formulated with many B-vitamins, which are an important requirement of the brains diet as they help form neurotransmitters (the chemical messengers of the nervous system). Pyridoxal phosphate, a vitamin B-6 member, is pivotal in the synthesis of the neurotransmitters serotonin, dopamine and gamma-amino butyric acid (GABA). For people who are over stimulated, GABA induces a balancing relaxation. Some people with anxiety, panic disorders, and depression may not manufacture sufficient levels of GABA. (22-28)
Some nutrient deficiencies can produce symptoms that are familiar as symptoms of hyperactivity and learning disorders. A deficiency of thiamin (vitamin B-1), for example, may produce irritability, nervousness and even increased sensitivity to noise. (29)
Some neurological childhood conditions appear to be connected to the B-vitamins. A study conducted at Saint Joseph Hospital in Pennsylvania found low serotonin (a neurotransmitter involved with mood) levels in hyperactive children. The researchers gave some of the subjects vitamin B-6 and observed their serotonin levels rise appreciably. Also, research suggests that a deficiency of vitamins B-2 and B-6 play a primary role in the cause of emotional disorders. (29, 30)
Vitamin B-12 deficiency can mimic Alzheimers disease: vitamin B-12 deficiency may cause fatigue, headaches, heart and nervous system disturbances such as numbness and tingling of the arms or legs, depression, mental confusion, and memory deficits. (20)
Vitamin C: Flavay Plus® also contains vitamin C: water-soluble, a potent free radical scavenger, recycles vitamin E, plays a primary role in the formation of collagen, essential for vascular health and a strong immune system. Controlled studies prove the contribution of vitamin C in the manufacture of white blood cells and interferon. (20, 21, 32, 33, 5)
It's also important to note that Flavay® dramatically extends the activity of vitamin C in the body.
Vitamin E: The bodys principal fat-soluble antioxidant. Much of the bodys free radical damage occurs in fats and in fatty membranes of cellsexactly where vitamin E protects the body. (20, 21, 32, 33, 5)
Selenium: Flavay Plus® includes selenium, as it is necessary for the bodys production of glutathione (an antioxidant produced by the body which protects the brain and nerve tissue from the harmful effects of free radicals) and thioredoxin reductase which recycles vitamin C. Selenium also has a synergistic effect with vitamin E, which means that the two combined are more powerful than either alone. Many Americans do not consume even the small RDA of selenium in their diet. (20, 21, 32, 33)
Zinc: Flavay Plus® also includes zinc because a number of studies are pointing to an association between zinc deficiency and ADHD. One such 1996 study, published in the Journal of Child Psychology and Psychiatry, revealed a statistically significant correlation between zinc and fatty acids, in that both were decreased in children with ADHD. In another study, conducted at Ohio State University, investigators found a relationship between zinc deficiency and response to stimulant therapy among people with ADHD. Basically, this study showed that children diagnosed with ADHD may be zinc deficient, and that this deficiency may result in their poor response to stimulant therapy. (4)
An essential mineral, zinc has many important effects on the brain and immune system, including neurotransmitter production and enzyme functioning. Zinc is a necessary part of the bodys production of DHA and a constituent of many vital enzymes, including superoxide dismutase (SOD), which is a critical cellular antioxidant enzyme that is responsible for mopping up peroxynitrate, the highly toxic free radical produced in abundance in the normal course of immune system battles (as in viral or bacterial infections) and plays a powerful role in immune system inflammation. Together with the B vitamins, zinc assists in the utilization of insulin and glucose. There is a growing body of evidence to indicate that zinc is needed for the proper maintenance of vitamin E levels in the blood and aids in the absorption of vitamin A. Other important functions of zinc include the promotion of glandular and reproductive health; and there is strong evidence that zinc is required for the synthesis of the nucleic acids RNA and DNA, which are essential for cell repair and cell growth. Studies have found large percentages of apparently healthy children to be deficient in zinc. There is evidence that zinc levels fall after physical and mental stress. Flavay Plus® uses zinc orotate, a high-quality, highly bioavailable form of zinc. (20, 21, 32, 33)
Flavay Plus® utilizes the dynamic interplay between these nutrients and their co-factors in order to provide you and your family with the best that nutritional science has to offer in a convenient, cost effective capsule.
Proven Safety of Flavay®
After more than 50 years of human use, no adverse effects have been observed. Furthermore, intensive biological, toxicological, pharmacological and analytical research was conducted for the purpose of registering it as a medicine in France and other countries in Europe. In one study, daily doses of up to 35,000 mg for six months were determined to cause no adverse effects. Flavay® was also clinically tested, in particular for all sorts of symptoms related to venolymphatic insufficiencies (strenghthening veins, improving circulation and reducing edema and inflammations). The spin-off is a goldmine of data: The rigorous testing to meet the standards required by the health ministries of France, Germany and other European countries demonstrate that Flavay® is highly bioavailable, nontoxic, nonallergenic, noncarcinogenic, nonmutagenic, will not cause birth defects, and is completely safe. (1, 2, 34-39)
Dr. Masqueliers unequaled manufacturing process has been conducted for half a century at the very same facilities in France, and under the control of French Pharmaceutical inspection. These time-proven standards serve as a reliable assurance of the quality, consistency, bioavailability and safety of Flavay®.
Who can take Flavay®?
Everyone, from the very young to elderly. Flavay® has no known contraindications (conditions under which it should not be used). Flavay® is completely safe and nontoxic. In fact, clinical trials have been conducted in which pregnant women (troubled by varicose veins and other circulatory problems in the legs) safely used Flavay®. (1)
Safety of Flavay Plus®
The essential vitamins and minerals in Flavay Plus® are naturally-derived and completely safe. Flavay Plus® includes phosphatidyl serine, derived from soy lecithin, which has been proven safe in standard toxicology tests. From the large number of human studies conducted, phosphatidyl serine has developed a flawless safety record and proven compatible with a wide array of medications. (9)
Altogether, this research shows that Flavay® and Flavay Plus® can help people of all ages confront the stressful challenges of living in today's world with improved concentration and attentionproviding you and your family with the best that nutritional science has to offer in convenient, cost effective capsules.
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